<p>The Many Therapeutic Applications of Nigella sativa - A Review of Literature.</p>

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Benkaci–Ali F, Baaliouamer A, Meklati BY, et al. Chemical composition of seed essential oils from Algerian Nigella sativa extracted by microwave and hydrodistillation. Flavour and Fragrance Journal 2007;22(2):148-53.           

Cheikh-Rouhou S, Besbes S, Hentati B, et al. Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction. Food Chemistry 2007;101(2):673-81.           

Hamrouni‐Sellami IB, Kchouk ME, Marzouk B. Lipid and aroma composition of black cumin (Nigella sativa L.) seeds from Tunisia. Journal of Food Biochemistry 2008;32(3):335-52.            

Kooti W, Hasanzadeh-Noohi Z, Sharafi-Ahvazi N, et al. Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chin J Nat Med 2016;14(10):732-45.                          

Takruri HRH, Dameh MAF. Study of the nutritional value of black cumin seeds (Nigella sativa L). Journal of the Science of Food and Agriculture 1998;76(3):404-10.                

Cheikh-Rouhou S, Besbes S, Hentati B, et al. Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction. Food Chemistry 2007;101(2):673-81.              

Sun L, Liu YM, Chen BQ, et al. New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells. Bioorg Med Chem Lett 2015;25(18):3864-6.                 

Chen QB, Xin XL, Aisa HA. Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity. Phytochemistry Letters 2017;19:168-71.                     

Saxena SN, Rathore SS, Diwakar Y, et al. Genetic diversity in fatty acid composition and antioxidant capacity of Nigella sativa L. genotypes. LWT 2017;78:198-207.                  

Arroo RRJ, Alfa HH. Chemical properties of thymoquinone, a monoterpene isolated from the seeds of Nigella sativa Linn. Pharmacol Res 2018;133:151.       

Ramadan MF, Kroh LW, Mörsel JT. Radical scavenging activity of black cumin (Nigella sativa L.), coriander (Coriandrum sativum L.), and niger (Guizotia abyssinica Cass.) crude seed oils and oil fractions. J Agric Food Chem 2003;51(24):6961-9.   

Kalus U, Pruss A, Bystron J, et al. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 2003;17(10):1209-14.              

Fararh KM, Atoji Y, Shimizu Y, et al. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet Sci 2004;77(2):123-9.           

Kocyigit Y, Atamer Y, Uysal E. The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats. Saudi Med J 2009;30(7):893-6.      

Amin KA, Nagy MA. Effect of carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetol Metab Syndr 2009;1(1):17.        

Bamosa AO, Kaatabi H, Lebdaa FM, et al. Effect of nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010;54(4):344-54.                          

Tembhurne SV, Feroz S, More BH, et al. A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plants Res 2014;8(3):167-77.          

Asgary S, Sahebkar A, Goli-Malekabadi N. Ameliorative effects of Nigella sativa on dyslipidemia. J Endocrinol Invest 2015;38(10):1039-46.

Prabhakar P, Reeta KH, Maulik SK, et al. Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats. Eur J Nutr 2015;54(7):1117-27.      

Hadi S, Mirmiran P, Hadi V, et al. Effects of Nigella sativa on cardiovascular risk factors. J Mazandaran Univ Med Sci 2016;25(134):430-42.           

Majdalawieh AF, Fayyad MW. Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med 2016;7(3):173-80.            

Ramalingam PS, Raj MAS, Ravichandran P, et al. Lipid peroxidation and anti-obesity activity of Nigella sativa seeds. World J Pharma Res 2017;6(10):882-92.

Pipalia PR, Annigeri RG, Mehta R. Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;122(6):705-12.

Koshak A, Koshak E, Heinrich M. Medicinal benefits of Nigella sativa in bronchial asthma: a literature review. Saudi Pharm J 2017;25(8):1130-6.       

Imran M, Rauf A, Khan IA, et al. Thymoquinone: a novel strategy to combat cancer: a review. Biomedicine & Pharmacotherapy 2018;106:390-402.             

Mahboubi M. Natural therapeutic approach of Nigella sativa (Black seed) fixed oil in management of Sinusitis. Integr Med Res 2018;7(1):27-32.          

Erisgin Z, Atasever M, Cetinkaya K, et al. Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats. Biomedicine & Pharmacotherapy 2019;110:742-7.                

Aisa HA, Xin XL, Tang D. Nigella sativa: a medicinal and edible plant that ameliorates diabetes. In: Watson RR, Preedy VR, eds. Bioactive food as dietary interventions for diabetes. Academic Press 2019:629-40.

Rogozhin EA, Oshchepkova YI, Odintsova TI, et al. Novel antifungal defensins from Nigella sativa L. seeds. Plant Physiol Biochem 2011;49(2):131-7.       

Effect of Hibiscus sabdariffa extract and Nigella sativa oil on the growth and aflatoxin B1 production of Aspergillus flavus and Aspergillus parasiticus strains. Food Control 2012;             

Rath S, Padhy RN. Monitoring in vitro antibacterial efficacy of 26 Indian spices against multidrug resistant urinary tract infecting bacteria. Integrative Medicine Research 2014;3(3):133-41.                  

Nadaf NH, Gawade SS, Muniv AS, et al. Exploring anti-yeast activity of Nigella sativa seed extracts. Industrial Crops and Products 2015;77:624-30.       

Bakal SN, Bereswill S, Heimesaat MM. Finding novel antibiotic substances from medicinal plants-antimicrobial properties of Nigella sativa directed against multidrug resistant bacteria. Eur J Microbiol Immunol 2017;7(1):92-8.                

Ashraf S, Anjum AA, Ahmad A, et al. In vitro activity of Nigella sativa against antibiotic resistant Salmonella enterica. Environ Toxicol Pharmacol 2018;58:54-8.           

Kiari FZ, Meddah B, Meddah AT. In vitro study on the activity of essential oil and methanolic extract from Algerian Nigella sativa L. Seeds on the growth kinetics of micro-organisms isolated from the buccal cavities of periodontal patients. The Saudi Dental Journal 2018;30(4):312-23.