A STUDY ON RELATIONSHIP BETWEEN FASTING PLASMA GLUCOSE, COPPER AND CERULOPLASMIN LEVELS IN TYPE 2 DIABETES MELLITUS.

CORRESPONDING AUTHOR:
Dr. Rangaswamy R,
Assistant Professor,
Department of Biochemistry,
Koppal Institute of Medical Sciences,
Koppal, Karnataka.
E-mail: rangaswamyr79@yahoo.com

ABSTRACT: INTRODUCTION: Diabetes mellitus (DM) is an endocrine disease associated with hyperglycemia characterized by both insulin resistance and defective insulin secretion. Copper a transition metal is present in many tissues like liver, muscle etc., It can oxidize proteins and lipids which lead to increased production of free radical compounds. Ceruloplasmin an alpha 2 globulin is an acute phase copper containing plasma protein synthesized mainly by hepatic parenchymal cells, lymphocytes etc., Reactive oxygen species (ROS)/ free radicals production due to hyperglycemia in diabetes mellitus can directly or indirectly alter the integrity and physiological function of cells. Present study was undertaken to study the relationship between fasting plasma glucose (FPG), copper and ceruloplasmin in type 2 Diabetes mellitus. MATERIALS AND METHODOLOGY: The study group consisted of a total 100 subjects which included non-diabetic healthy control subjects (n = 50) and type 2 diabetic patients (n = 50). Fasting blood samples were collected and analysed for estimation of fasting plasma glucose, serum copper and ceruloplasmin. RESULTS: Results shows increase in levels of copper and FPG (P<0.001) and decrease in ceruloplasmin (P<0.001) in type 2 DM patients compared to healthy controls. CONCLUSION: Our study shows an increase in copper and FPG with decreased levels of ceruloplasmin which may be due to generation of ROS which leads to increased consumption of available antioxidants in the body.

KEYWORDS: Fasting plasma glucose (FPG), Copper, Ceruloplasmin, Type 2Diabetes Mellitus.