Table of Contents

2019 Month : September Volume : 8 Issue : 35 Page : 2733-2737

Cardiac Autonomic Neuropathy- An ECG Correlation in Type 2 Diabetes.

Subashini Vijayan1, Ganesamoorthy K.2, Usha Padmini3, Ravikumar T.4

Corresponding Author:
Subashini Vijayan,
#202, Third Floor q2 Apartment,
ESI Quarters, Varadharajapuram,
Coimbatore-641015, Tamilnadu, India.



Cardiac autonomic neuropathy is a serious complication with poor prognosis in type 2 diabetes. It is asymptomatic in diabetes. It results in increased incidence of silent myocardial infarction and ischemia and left ventricular dysfunction. Diabetic cardiac autonomic neuropathy (CAN) a serious microvascular complication with poor prognosis. Diabetic cardiac autonomic neuropathy (CAN), a major complication seen in one-sixth of insulin dependent type 1 diabetes and one-third of non-insulin dependent diabetic patients, is related with increased morbidity. We wanted to study the ECG and ECHO changes in type 2 diabetes to diagnose cardiac autonomic neuropathy.


This was a case control study and sample size was taken for convenience. Patients attending diabetes and medical OPD in a teaching hospital were selected according to inclusion and exclusion criteria. Hundred patients of type 2 diabetes mellitus of more than five years duration and 100 age and sex matched controls without any history of diabetes were selected. ECG and ECHO were done in all cases and controls.


A total of 100 type 2 diabetes patients and 100 age matched controls were studied. QTc interval prolongation occurs with development of CAN. Prolongation of QTc interval is well correlated with Cardiac Autonomic Neuropathy in type 2 diabetes.


QTc interval is easily measurable and is a non-invasive method. It is the earliest sign of cardiac autonomic neuropathy. It is prolonged in type 2 diabetes patients with severe cardiac autonomic dysfunction. They have a high risk of developing silent myocardial infarction and sudden death. Early diagnosis and early control of sugar will prevent morbidity in diabetic individuals.


Cardiac Autonomic Neuropathy, Type 2 Diabetes, Myocardial Infarction, Coronary Artery Disease QT Dispersion ECG

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