Table of Contents

2019 Month : January Volume : 8 Issue : 2 Page : 104-110

EFFECTIVENESS OF CONVENTIONAL VS. HYPO FRACTIONATED RT SCHEDULES FOR CHEST WALL IRRADIATION IN BREAST CANCER TREATMENT AND OUTCOME.

Suresh Kumar K1, Kiran P2, Joneetha Jones3, Mintu Mathew4, Snigdha P. P5

Corresponding Author:
Dr. Kiran P,
Assistant Professor,
Department of Radiotherapy and Oncology,
Cancer Care Center Medical College,
Kottayam, Kerala,
India.
E-mail: kiranphere@gmail.com

ABSTRACT

BACKGROUND

Post mastectomy radiotherapy for patients with positive nodes derives a disease-free survival and overall survival benefit. Radiobiological models suggest that hypo fractionation might be equally effective for adjuvant RT in breast cancer. Evidence has been convincing, and this is now being accepted as standard practice.

MATERIALS AND METHODS

This retrospective cohort study compares the two fractionation schedules in Carcinoma Breast used in post mastectomy chest wall irradiation (50 Gy/25 fractions vs 40 Gy/ 15 fractions) regarding loco-regional control and toxicity profile. Patients were accrued from March 2011 to August 2013 and were followed up for a period of 1 year. A total of 195 patients were included in the study.

RESULTS

The baseline characteristics were similar in both arms. No statistically significant difference in disease free survival was seen between the two arms. The toxicity profile was also comparable.

CONCLUSION

After mastectomy for breast cancer, a radiotherapy schedule delivering 40 Gy in 15 fractions over 3 weeks seems to offer local regional tumour control and rates of normal tissue effects are at least as good as the accepted international standard of 50 Gy in 25 fractions over 5 weeks

KEY WORDS

Breast Cancer, Radiation, Hypofractionation.a

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