Comparison of the Post-Operative Response of Tumour Necrosis Factor- α and Interleukin-6 in Inguinal Hernioplasty.

Corresponding Author:
Nawin Kumar,
Department of General Surgery,
Justice K. S. Hegde Charitable Hospital,
Deralakatte, Mangluru-575018,
Karnataka, India.
E-mail: neonawin@gmail.com

ABSTRACT

BACKGROUND

Inguinal hernia is the commonest groin swelling. Some of the common predisposing factors to inguinal hernia are COPD, BPH and chronic constipation. This study aims to determine the post-operative significance of Interleukin-6 (IL-6) and Tumour Necrosis Factor-α (TNF-α) following open- and laparoscopic- TEP repair inguinal hernioplasty in the detection of tissue trauma.

METHODS

This study was conducted in the department of General Surgery from January 2017- June 2018 in Justice K. S. Hegde Charitable Hospital. The post-operative response of IL-6 and TNF-α was assessed among 40 patients undergoing open and laparoscopic-TEP repair inguinal hernioplasty. Mann-Whitney U test was used and the p-Value of <0.05 is considered statistically significant.

RESULTS

The post-operative rise in TNF-α following laparoscopic hernioplasty was statistically significant when compared to the open procedure (unilateral hernioplasty: p-Value- 0.04 and bilateral hernioplasty: p-Value- 0.009). No significant change was noted in IL-6 (unilateral hernioplasty: p-Value– 0.65 and Bilateral hernioplasty: p-Value– 0.29)

CONCLUSIONS

The post-operative change in TNF-α was considered significant when compared to IL-6. Thus, showing that TNF- α is a more reliable indicator of tissue trauma.

KEY WORDS

Tumour Necrosis Factor– α, Interleukin- 6 Inguinal Hernioplasty