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2019 Month : November Volume : 8 Issue : 47 Page : 3505-3507

Comparison of the Post-Operative Response of Tumour Necrosis Factor- α and Interleukin-6 in Inguinal Hernioplasty.

Rohith Holla1, Nawin Kumar2

Corresponding Author:
Nawin Kumar,
Department of General Surgery,
Justice K. S. Hegde Charitable Hospital,
Deralakatte, Mangluru-575018,
Karnataka, India.



Inguinal hernia is the commonest groin swelling. Some of the common predisposing factors to inguinal hernia are COPD, BPH and chronic constipation. This study aims to determine the post-operative significance of Interleukin-6 (IL-6) and Tumour Necrosis Factor-α (TNF-α) following open- and laparoscopic- TEP repair inguinal hernioplasty in the detection of tissue trauma.


This study was conducted in the department of General Surgery from January 2017- June 2018 in Justice K. S. Hegde Charitable Hospital. The post-operative response of IL-6 and TNF-α was assessed among 40 patients undergoing open and laparoscopic-TEP repair inguinal hernioplasty. Mann-Whitney U test was used and the p-Value of <0.05 is considered statistically significant.


The post-operative rise in TNF-α following laparoscopic hernioplasty was statistically significant when compared to the open procedure (unilateral hernioplasty: p-Value- 0.04 and bilateral hernioplasty: p-Value- 0.009). No significant change was noted in IL-6 (unilateral hernioplasty: p-Value– 0.65 and Bilateral hernioplasty: p-Value– 0.29)


The post-operative change in TNF-α was considered significant when compared to IL-6. Thus, showing that TNF- α is a more reliable indicator of tissue trauma.


Tumour Necrosis Factor– α, Interleukin- 6 Inguinal Hernioplasty

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