AUTOLOGOUS PLATELET RICH PLASMA (PRP) VERSUS LEUCOCYTE-PLATELET RICH FIBRIN (L-PRF) IN CHRONIC NON-HEALING LEG ULCERS - A RANDOMISED, OPEN LABELLED, COMPARATIVE STUDY.

Corresponding Author:
Dr. Azariah Johnson Samuel Pravin,
No. 80, Henry Road, Nagercoil-629001,
KK District, Tamilnadu.
E-mail: shahilapravin@gmail.com

ABSTRACT

BACKGROUND

Our aim was to evaluate and compare the efficacy of Platelet-Rich Plasma (PRP) and Leucocyte Platelet Rich Fibrin (L-PRF) in the treatment of chronic non-healing leg ulcers.

MATERIALS AND METHODS

A randomised, open labelled comparative study was performed on 30 patients with non-healing ulcers of various aetiologies. 15 patients were treated with PRP and 15 patients with L-PRF at weekly intervals for a maximum of 6 treatments. At the end of the 6-week period, reduction in size of the ulcers (Area and volume) was assessed.

RESULTS

Of 30 ulcers, there were 22 venous ulcers, 1 ulcer due to vasculitis, 1 traumatic ulcer, 2 diabetic ulcers and 4 trophic ulcers. The mean duration of healing of the ulcers were 5.7 weeks in L-PRF and 6.5 in PRP (p = 0.034). About 100% resolution was seen in 11 of the ulcers in L-PRF and 8 of the ulcers in PRP at the end of the 6th treatment (73.3% vs. 53.3%).

CONCLUSION

L-PRF is more efficacious and has a quicker healing rate than PRP, probably due to its anti-inflammatory effects and also protection against infections. L-PRP will be more promising in future than PRP in treating chronic ulcers.

KEYWORDS

Leg Ulcers, Platelet rich Plasma, Leucocyte Platelet Rich Fibrin.